Surfactin Inhibits Membrane Fusion during Invasion of Epithelial Cells by Enveloped Viruses
نویسندگان
چکیده
منابع مشابه
Structural basis for membrane fusion by enveloped viruses.
Enveloped viruses such as HIV-1, influenza virus, and Ebola virus express a surface glycoprotein that mediates both cell attachment and fusion of viral and cellular membranes. The membrane fusion process leads to the release of viral proteins and the RNA genome into the host cell, initiating an infectious cycle. This review focuses on the HIV-1 gp41 membrane fusion protein and discusses the str...
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Viruses use elaborate stratagems to enter cells. The HIV-1 envelope glycoprotein, which mediates both attachment and membrane fusion, has grudgingly begun to yield high-resolution structural information that suggests mechanistic similarities with the hemagglutinin protein of influenza virus.
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Experiments in the 1960s showed that Sendai virus, a paramyxovirus, fused its membrane with the host plasma membrane. After membrane fusion, the virus spontaneously "uncoated" with diffusion of the viral membrane proteins into the host plasma membrane and a merging of the host and viral membranes. This led to deposit of the viral ribonucleoprotein (RNP) and interior proteins in the cell cytopla...
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Viral infection requires the binding of receptors on the target cell membrane to glycoproteins, or “spikes,” on the viral membrane. The initial entry is usually classified as fusogenic or endocytotic. However, binding of viral spikes to cell surface receptors not only initiates the viral adhesion and the wrapping process necessary for internalization, but can simultaneously initiate direct fusi...
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Infection by membrane-enveloped viruses requires the binding of receptors on the target cell membrane to glycoproteins, or "spikes," on the viral membrane. The initial entry mechanism is usually classified as fusogenic or endocytotic. However, binding of viral spikes to cell surface receptors not only initiates the viral adhesion and the wrapping process necessary for internalization, but can s...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2018
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00809-18